臺北醫學大學 臺北神經醫學中心 校級神經醫學研究中心

北醫神經婦幼團隊

北醫神經婦幼團隊由公衛學院陳怡樺院長帶領，結合了公衛精神流行病學與環境科學專家、婦產小兒神經與早療臨床醫師組成專業團隊，因應當前少子化危機，關注嬰幼兒發展能否順應環境的巨大變動，並經由長期追蹤探討環境對於孩童身心健康的影響。本團隊自2009年積極投入此議題，並共同為嬰幼兒成長與健康努力，同時關注父母親的整體身心狀態，認為家庭整體健康為社區、群體乃至於國家未來發展之重要關鍵。

本團隊在當前以科技導入健康之重要契機，持續擴充大型「臺灣孕產期健康追蹤研究」長期追蹤資料庫優勢，最大特色莫過於納入影響幼兒發展舉足輕重卻少有文獻支持之議題，包括睡眠、多媒體使用、飲食習慣、室內室外空氣污染與重金屬暴露等之危害。過去研究對象大多集中於3-12歲的兒童，並已指出危害與風險，然針對1-3歲幼兒關鍵期的研究明顯不足，且鮮少能對嬰幼兒以長期追蹤研究整合探討各因子連動與交互作用，及其對幼兒認知語言發展之權重影響力，因此本團隊之特色為利用長期追蹤資料結合家訪採樣調查、收集親子之睡眠品質與體內重金屬含量、家戶環境與空氣品質採樣以及幼兒語言發展與腦部神經發展狀況，再經由人工智慧多模態資訊平台，建立幼兒神經發展預測模型，並有助於醫事人員選取適當的早療決策，進而達到預防醫學與精準公衛之願景。

發表文章

• 1. Hsueh-Wen Hsu, Jian-Pei Huang, Heng-Kien Au, Chen-Li Lin, Yi-Yung Chen, Ling-Chu Chien, Hsing Jasmine Chao, Yu-Chun Lo, Wen-Yi Lin, Yi-Hua Chen. (2024). Impact of miscarriage and termination of pregnancy on subsequent pregnancies: A longitudinal study of maternal and paternal depression, anxiety and eudaimonia. Journal of Affective Disorders. Volume 354, 1 June 2024, Pages 544-552. https://doi.org/10.1016/j.jad.2024.03.054
• 2. Hsiao-Chun Huang, Ming-Lun Zou, Yi-Hua Chen, Chuen-Bin Jiang, Chih-Da Wu, Shih-Chun Candice Lung, Ling-Chu Chien, Yu-Chun Lo, Hsing Jasmine Chao. (2023, Nov). Effects of indoor air quality and home environmental characteristics on allergic diseases among preschool children in the Greater Taipei Area. Science of the Total Environment. Science of The Total Environment, Volume 897, 1 November 2023, 165392. nstc 107-2314-B-038-075-MY3.
• 3. Chi-Sian Kao, Yen-Tzu Fan, Ying-Lin Wang, Yi-Hua Chen, Hsing-Jasmine Chao, Yu-Chun Lo, Chuen-Bin Jiang & Ling-Chu Chien. (2023, Oct). Associations between parental and postnatal metal mixture exposure and developmental delays in a Taiwanese longitudinal birth cohort of preschool children. Environmental Science and Pollution Research, doi: 10.1007/s11356-023-30435-6.
• 4. Hsin-Yi Wu, Wen-Yi Lin, Jian-Pei Huang, Chen-Li Lin, Heng-Kien Au, YuChun Lo, Ling-Chu Chien, Hsing Jasmine Chao, Yi-Hua Chen. (2023, Jul). Effects of mobile device use on emotional and behavioral problems in the CBCL among preschoolers: Do shared reading and maternal depression matter?. PLoS One, 2023; 18(7): e0280319. nstc 108-2813-C-038-062-B.
• 5. Yong-Sin Li, Hsin-Chien Lee, Jian-Pei Huang, Ya-Zhu Lin, Heng-Kien Au, YuChun Lo, Ling-Chu Chien, Hsing-Jasmine Chao, Wanda Estinfort, Yi-Hua Chen. (2023, May). Adverse effects of inadequate sleep duration patterns during pregnancy on toddlers suspected developmental delay: A longitudinal study. Sleep Medicine, 105:68-77. nstc 111-2314-B-038-043-MY3. MOST 111-2314-B-038-043-MY3, MOST 108-2314-B-038-083-MY3, MOST 105-2314-B-038-031-MY3, NSC 102-2314-B-038-038-MY3, and NSC 99-2628-B-038-015-MY3.
• 6. Yohane V.A. Phiri, Meei-Maan Wu, Yi-Hua Chen, Ming-Lun Zou, Chuen-Bin Jiang, Chih-Da Wu, Hsiao-Chun Huang, Shih-Chun Candice Lung, Ling-Chu Chien, Yu-Chun Lo, Fang-Yu Lee, Hsing Jasmine Chao. (2023, Feb). Environmental determinants of household microbial and allergen levels in the Greater Taipei Area. Building and Environment, 230, 110003.
• 7. Ming-Lun Zou, Hsiao-Chun Huang, Yi-Hua Chen, Chuen-Bin Jiang, Chih-Da Wu, Shih-Chun Candice Lung, Ling-Chu Chien, Yu-Chun Lo, Hsing Jasmine Chao. (2023, Jan). Sex-differences in the effects of indoor air pollutants and household environment on preschool child cognitive development. Science of The Total Environment. (SCI).
• 8. Zou, M.-L., Huang, H.-C., Chen, Y.-H., Jiang, C.-B., Wu, C.-D., Lung, S.-C. C., . . . Chao, H. J. (2022). Sex-differences in the effects of indoor air pollutants and household environment on preschool child cognitive development. Science of The Total Environment, 160365. doi:https://doi.org/10.1016/j.scitotenv.2022.160365
• 9. Estinfort, W., Huang, J. P., Au, H. K., Chen, L. L., Chen, Y. Y., Chao, H. J., … & Chen, Y. H. (2022). Effects of prenatal subjective well-being on birth outcomes and child development: A longitudinal study. European Psychiatry, 1-29.
• 10. 張歆祐、陳怡婷、陳怡樺. （2022年03月）。台灣低憂鬱孕產婦正向心理因素初探(Preliminary study on the positive psychological factors of pregnant and postpartum women with low depression in Taiwan)。中華心理衛生學刊。
• 11. Zou, M. L., Jiang, C. B., Chen, Y. H., Wu, C. D., Lung, S. C. C., Chien, L. C., … & Chao, H. J. (2022). Frequent occurrence of respiratory symptoms in children is associated with exposure to air pollution, land use types, and parental mental health in the Greater Taipei area. Environmental Research, 206, 112567.
• 12. Kao, C. S., Wang, Y. L., Jiang, C. B., Chuang, Y. C., Chen, Y. H., Hsi, H. C., & Chien, L. C. (2022). Associations of maternal food safety-related risk perceptions and protective behaviors with daily mercury intake and internal doses of Taiwanese women and their preschool children. Environmental Research, 212, 113344.
• 13. Santri, I. N., Jiang, C.-B., Chen, Y.-H., Wu, C.-D., Zou, M.-L., Chien, L.-C., . . . Chao, H. J. (2021). Associations of birth outcomes with air pollution and land use characteristics in the Greater Taipei Area. Science of The Total Environment, 750, 141579. doi:https://doi.org/10.1016/j.scitotenv.2020.141579
• 14. Wang, H.-Y., Huang, J.-P., Lin, C.-l., Au, H.-K., & Chen, Y.-H. (2020). Paternal influences from early pregnancy to postpartum years on child development: A longitudinal study. Journal of Affective Disorders, 275, 23-30. doi:https://doi.org/10.1016/j.jad.2020.06.018
• 15. Alibekova, R., Huang, J.-P., Lee, T. S.-H., Au, H.-K., & Chen, Y.-H. (2020). Corrigendum to “Effects of smoking on perinatal depression and anxiety in mothers and fathers: A prospective cohort study” Journal of Affective Disorders 193(2016) 18-26]. Journal of Affective Disorders, 274, 1218. doi:https://doi.org/10.1016/j.jad.2020.05.135
• 16. Chen, Y.-H., Huang, J.-P., Au, H.-K., & Chen, Y.-H. (2019). High risk of depression, anxiety, and poor quality of life among experienced fathers, but not mothers: A prospective longitudinal study. Journal of Affective Disorders, 242, 39-47.doi:https://doi.org/10.1016/j.jad.2018.08.042