臺北醫學大學 臺北神經醫學中心 校級神經醫學研究中心

研究亮點

在醫學領域中，睡眠醫學雖然發展得較晚。北醫大體系自2005年在附設醫院開啟睡眠醫學臨床服務後，目前三家附屬醫院皆設有睡眠中心，在醫學院下亦設置睡眠研究中心，同時也在校內開設多們睡眠醫學相關課程。

研究上以睡眠呼吸中止與睡眠剝奪及失眠為兩大主軸。在神經醫學領域中，睡眠具有極重要角色。睡眠不僅為大腦所有，被大腦所管理，健康的睡眠更有助於維護大腦健康。反之，睡眠剝奪及失眠，也容易影響腦神經功能，更與神經退化有緊密關係。

神經醫學研究中心的睡眠研究團隊，由不同領域的基礎與臨床研究人員所組成。進行中的研究涵蓋動物睡眠研究，人類睡眠研究與睡眠醫學實證研究。從睡眠生理的基礎，睡眠障礙的機轉，到睡眠疾病的介入，均有所涉獵並有研究成果。睡眠研究團隊，希望結合北醫大校內外的睡眠醫學研究能量，以一窺睡眠的奧秘，並為越來越盛行的睡眠疾患，提供醫療對策。

研究成果

• 1. Hasan, F., Tu, Y.-K., Yang, C.-M. and 7 more (…) (2022).Comparative efficacy of digital cognitive behavioral therapy for insomnia: A systematic review and network meta-analysis. Sleep Medicine Reviews,61
• 2. He, Y., Liu, W., Lin, S. and 5 more (…) (2022).Association of traffic air pollution with severity of obstructive sleep apnea in urban areas of Northern Taiwan: A cross-sectional study. Science of the Total Environment,827
• 3. Lo, C.-C., Liu, W.-T., Lu, Y.-H. and 13 more (…) (2022).Air pollution associated with cognitive decline by the mediating effects of sleep cycle disruption and changes in brain structure in adults. Environmental Science and Pollution Research,29(35) 52355-52366
• 4. Tsai, C.-Y., Liu, W.-T., Lin, Y.-T. and 13 more (…) (2022).Machine learning approaches for screening the risk of obstructive sleep apnea in the Taiwan population based on body profile. Informatics for Health and Social Care,47(4) 373-388
• 5. Lai, W.-D., Tung, T.-H., Teng, C.-Y. and 5 more (…) (2022).Fish oil ameliorates neuropsychiatric behaviors and gut dysbiosis by elevating selected microbiota-derived metabolites and tissue tight junctions in rats under chronic sleep deprivation. Food & function,13(5) 2662-2680
• 6. Tsai, C.-Y., Hsu, W.-H., Lin, Y.-T. and 13 more (…) (2022).Associations among sleep-disordered breathing, arousal response, and risk of mild cognitive impairment in a northern Taiwan population. Journal of Clinical Sleep Medicine,18(4) 1003-1012
• 7. Kuan, Y.C., Hong, C.T., Chen, P.C. and 2 more (…) (2022).Logistic regression and artificial neural network-based simple predicting models for obstructive sleep apnea by age, sex, and body mass index. Mathematical Biosciences and Engineering,19(11) 11409-11421
• 8. Liu, W.-T., Wang, Y.-H., Chang, L.-T. and 10 more (…) (2022).The impacts of ambient relative humidity and temperature on supine position-related obstructive sleep apnea in adults. Environmental Science and Pollution Research,29(33) 50755-50764
• 9. Yang, C.-M., Lai, Y.-S., Huang, Y.-H. and 2 more (…) (2022).Predicting Hypnotic Use among Insomnia Patients with the Theory of Planned Behavior and Craving. Behavioral Sciences,12(7)
• 10. Tsai, C.-Y., Liu, Y.-S., Majumdar, A. and 18 more (…) (2022).Association between cyclic variation in the heart rate index and biomarkers of neurodegenerative diseases in obstructive sleep apnea syndrome: A pilot study. Journal of Clinical Neuroscience,9837-44
• 11. Shih, C.-Y., Gordon, C.J., Chen, T.-J. and 4 more (…) (2022).Comparative efficacy of nonpharmacological interventions on sleep quality in people who are critically ill: A systematic review and network meta-analysis. International Journal of Nursing Studies,130
• 12. Tsai, C.-Y., Kuan, Y.-C., Hsu, W.-H. and 15 more (…) (2022).Differentiation model for insomnia disorder and the respiratory arousal threshold phenotype in obstructive sleep apnea in the taiwanese population based on oximetry and anthropometric features. Diagnostics,12(1)
• 13. Qiu, H., Liu, W.-T., Lin, S.-Y. and 6 more (…) (2022).Association of air pollution exposure with low arousal threshold obstructive sleep apnea: A cross-sectional study in Taipei, Taiwan. Environmental Pollution,306
• 14. Susanti, H.D., Sonko, I., Chang, P.-C. and 2 more (…) (2022).Effects of yoga on menopausal symptoms and sleep quality across menopause statuses: A randomized controlled trial. Nursing and Health Sciences,24(2) 368-379
• 15. Hasan, F., Tu, Y.-K., Lin, C.-M. and 5 more (…) (2022).Comparative efficacy of exercise regimens on sleep quality in older adults: A systematic review and network meta-analysis. Sleep Medicine Reviews,65
• 16. Li, C.-H., Chung, M.-H., Liao, C.-H. and 3 more (…) (2022).Urinary Incontinence and Sleep Quality in Older Women with Type 2 Diabetes: A Cross-Sectional Study. International Journal of Environmental Research and Public Health,19(23)
• 17. Pujasari, H., Chung, M.-H. (2022).Sleep Disturbance in the Context of HIV: A Concept Analysis. SAGE Open Nursing,8
• 18. Lin, Y.-C., Chen, C.-T., Chao, P.-Z. and 5 more (…) (2022).Prevention of Incident Hypertension in Patients With Obstructive Sleep Apnea Treated With Uvulopalatopharyngoplasty or Continuous Positive Airway Pressure: A Cohort Study. Frontiers in Surgery,9
• 19. Shih, C.-Y., Wang, A.-Y., Chang, K.-M. and 6 more (…) (2022).Dynamic prevalence of sleep disturbance among critically ill patients in intensive care units and after hospitalisation: A systematic review and meta-analysis. Intensive and Critical Care Nursing
• 20. Tung, N.T., Lin, S.-Y., Liu, W.-T. and 6 more (…) (2022).Higher Particulate Matter Deposition in Alveolar Region Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea. ACS Environmental Au
• 21. Tung, N.T., Lin, S.-Y., Dung, H.B. and 7 more (…) (2022).Associations of overnight changes in body composition with positional obstructive sleep apnea. Sleep and Breathing
• 22. Tsai, C.-Y., Wu, S.-M., Kuan, Y.-C. and 13 more (…) (2022).Associations between risk of Alzheimer’s disease and obstructive sleep apnea, intermittent hypoxia, and arousal responses: A pilot study. Frontiers in Neurology,13
• 23. Tsai, C.-Y., Huang, H.-T., Cheng, H.-C. and 14 more (…) (2022).Screening for Obstructive Sleep Apnea Risk by Using Machine Learning Approaches and Anthropometric Features. Sensors,22(22)
• 24. Lai, M.-H., Tzeng, C.-Y., Chuang, Y.-H. and 2 more (…) (2022).Coping with the Experience of Bad Sleep and Fatigue Associated with the Nursing Clinical Practicum. International Journal of Environmental Research and Public Health,19(12)
• 25. Kung, Y.-C., Li, C.-W., Hsiao, F.-C. and 7 more (…) (2022).Cross-Scale Dynamicity of Entropy and Connectivity in the Sleeping Brain. Brain connectivity,12(9) 835-845
• 26. Amelia, V.L., Jen, H.-J., Lee, T.-Y. and 2 more (…) (2022).Comparison of the Associations between Self-Reported Sleep Quality and Sleep Duration Concerning the Risk of Depression: A Nationwide Population-Based Study in Indonesia. International Journal of Environmental Research and Public Health,19(21)